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Jaspamycin
$350 – $2,250
Products Details
Product Description
– Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].
Web ID
– HY-111759
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C12H12N4O5
References
– [1]Sabine Bachmaier, et al. Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 2019 Mar 29;10(1):1421.
CAS Number
– 22242-96-2
Molecular Weight
– 292.25
Compound Purity
– 98.60
SMILES
– O=C1C2=C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=C2C#N)N=CN1
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 41.67 mg/mL (ultrasonic)
Target
– Parasite;PKA
Isoform
– PKA;PKAR;Trypanosoma
Pathway
– Anti-infection;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
