Jaspamycin

$350$2,250

Products Details

Product Description

– Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].

Web ID

– HY-111759

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C12H12N4O5

References

– [1]Sabine Bachmaier, et al. Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 2019 Mar 29;10(1):1421.

CAS Number

– 22242-96-2

Molecular Weight

– 292.25

Compound Purity

– 98.60

SMILES

– O=C1C2=C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=C2C#N)N=CN1

Clinical Information

– No Development Reported

Research Area

– Infection

Solubility

– DMSO : 41.67 mg/mL (ultrasonic)

Target

– Parasite;PKA

Isoform

– PKA;PKAR;Trypanosoma

Pathway

– Anti-infection;Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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