Products Details

Product Description

– JAK3-IN-9 is an orally active JAK3 inhibitor with IC50 value of 1.7 nM. JAK3-IN-9 is highly selective to the JAK3 signal path. JAK3-IN-9 is lowly toxic with high oral bioavailability, shows good anti-arthritis activity. JAK3-IN-9 can be used in autoimmune disease research[1].

Web ID

– HY-133747

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C17H23N5O4S

References

– [1]Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851.

CAS Number

– 1430095-30-9

Molecular Weight

– 393.46

SMILES

– CC(C)[C@@H](C)NC1=C(C(N)=O)C=NC(NC2=CC=C(OS(=O)(C)=O)C=C2)=N1

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– JAK

Isoform

– JAK3

Pathway

– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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