Products Details

Product Description

– JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].

Web ID

– HY-147975

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C19H19N5O4S

References

– [1]Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851.

CAS Number

– 1430095-86-5

Molecular Weight

– 413.45

SMILES

– CS(=O)(OC1=CC=C(NC2=NC=C(C(N)=O)C(NCC3=CC=CC=C3)=N2)C=C1)=O

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– JAK

Isoform

– JAK1;JAK2;JAK3

Pathway

– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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