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JAK2 JH2 binder-1
$640 – $2,560
Products Details
Product Description
– JAK2 JH2 binder-1 (compound 11) is a potent and selective JAK2 JH2 binder, with a Kd of 37.1 nM. JAK2 JH2 binder-1 has the potential for various myeloproliferative neoplasms research[1].
Web ID
– HY-146186
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H25N7O6S
References
– [1]Losi ME, et, al. Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands. J Med Chem. 2022 Jun 23;65(12):8380-8400.
CAS Number
– 2923309-41-3
Molecular Weight
– 599.62
Compound Purity
– 95.47
SMILES
– NC1=NC(NC2=CC=C(C=C2)S(=O)(N)=O)=NN1C(NC3=CC=C(C=C3)C4=CC(C(O)=O)=C(C=C4)OCC5=CC=CC=C5)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JAK
Isoform
– JAK2
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
