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Products Details
Product Description
– JAK2-IN-9 (Compound A8) is a selective JAK2 inhibitor (IC50: 5 nM). JAK2-IN-9 inhibits the phosphorylation of JAK2, STAT3, and STAT5. JAK2-IN-9 has metabolic stabilities. JAK2-IN-9 induces apoptosis. JAK2-IN-9 can be used for research of myeloproliferative neoplasms (MPNs)[1].
Web ID
– HY-155746
Shipping
– Room temperature
Molecular Formula
– C20H24N6O2S
References
– [1]Tian Y, et al Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors. ACS Med Chem Lett. 2023 Aug 1;14(8):1113-1121.
CAS Number
– 2568842-26-0
Molecular Weight
– 412.51
SMILES
– C=CS(=O)(NCC1=CC=C(NC2=NC=C(C)C(C3=CN(C(C)C)N=C3)=N2)C=C1)=O
Clinical Information
– No Development Reported
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– JAK
Isoform
– JAK2
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
