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Products Details
Product Description
– JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC50 = 29 and 41 nM respectively).
Web ID
– HY-145336
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H20F3N7O
References
– [1]Fensome A, et al. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg Med Chem. 2020 May 15;28(10):115481.
CAS Number
– 1883300-48-8
Molecular Weight
– 407.39
SMILES
– O=C([C@H]1C(F)(C1)F)N[C@]23[C@](CN(C4=NC(NC5=CN(C)N=C5)=NC=C4F)C3)([H])[C@H]2C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JAK
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
