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Products Details
Product Description
– JAK1-IN-9 (compound 23a) is a potent and selective JAK1 inhibitor with an IC50 of 72 nM. JAK1-IN-9 shows selective against other JAKs by 12 times or more[1].
Web ID
– HY-144440
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H13IN6
References
– [1]WooChan Kim, et al. Synthesis and structure-activity relationship studies of 1,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 1 (JAK1) inhibitors. Bioorg Med Chem Lett. 2022 Jan 1;55:128451.
CAS Number
– 2875041-96-4
Molecular Weight
– 416.22
SMILES
– CC1=C(N=NN1CC2=CC=C(C=C2)I)C3=C4C=CNC4=NC=N3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JAK
Isoform
– JAK1;JAK2
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
