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Products Details
Product Description
– JAK kinase-IN-1 (Example 1) is a JAK inhibitor. JAK kinase-IN-1 inhibits TYK2, JAK1, JAK2 and JAK3 with IC50 values of 4.2 nM, 32 nM, 27 nM, 3473 nM respectively[1].
Web ID
– HY-156535
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H19F2N7OS
References
– [1]Yao, Yuanshan, et al. Preparation of (pyrimidinyl)thiadiazabicyclo[3.2.1]octane derivatives as JAK kinase inhibitor and used for preventing and/or treating diseases or disorders related to JAK kinase activity or expression. Patent. WO2021180143.
CAS Number
– 2698389-43-2
Molecular Weight
– 407.44
SMILES
– O=C([C@H]1C(F)(F)C1)N([C@H](CS2)C3)[C@@H]2CN3C4=CC=NC(NC5=CN(C)N=C5)=N4
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– JAK
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
