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JAK-IN-3
$410 – $3,400
Products Details
Product Description
– JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively[1].
Web ID
– HY-111750
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H20N4O3
References
– [1]Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10(3):306-311.
CAS Number
– 1400876-94-9
Molecular Weight
– 340.38
Compound Purity
– 98.92
SMILES
– O=C(C1=C(N[C@@H]([C@H](O)C)CO)C2=CC(C3=CC=CC=C3)=CN2N=C1)N
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– JAK
Isoform
– JAK1;JAK2;JAK3;Tyk2
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
