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J30-8
$85 – $780
Products Details
Product Description
– J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases[1].
Web ID
– HY-125838
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C17H9ClFN3O2S
References
– [1]Dou X, et al. Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. J Med Chem. 2019 Jul 25;62(14):6645-6664.
CAS Number
– 2366255-71-0
Molecular Weight
– 373.79
Compound Purity
– 99.90
SMILES
– O=C1N/C(S/C1=C2C(NC3=C2C=C(F)C=C3)=O)=N/C4=CC=CC=C4Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Target
– JNK
Isoform
– JNK3
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
