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J-147
$99 – $319
Products Details
Product Description
– J-147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J-147 can readily pass the blood brain barrier (BBB)[1]. J-147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively[2]. J-147 has potential for the treatment of Alzheimer’s disease (AD)[3].
Web ID
– HY-13779
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C18H17F3N2O2
References
– [1]Prior M, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer’s disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25.|[2]Chen Q, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer’s disease. PLoS One. 2011;6(12):e27865.|[3]Prior M, et al. Selecting for neurogenic potential as an alternative for Alzheimer’s disease drug discovery. Alzheimers Dement. 2016 Jun;12(6):678-86.|[4]Wang M, et al. The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer’s disease. Bioorg Med Chem Lett. 2013 Jan 15;23(2):524-7.
CAS Number
– 1146963-51-0
Molecular Weight
– 350.34
Compound Purity
– 99.80
SMILES
– O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F
Clinical Information
– Phase 1
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Dopamine Transporter;Monoamine Oxidase
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
