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IW927
$390 – $2,100
Products Details
Product Description
– IW927 is a potent small molecule antagonist that blocks the binding of TNF-α to TNFRc1 with an IC50 value of 50 nM and disrupts TNFα-induced IκB phosphorylation with an IC50 value of 600 nM[1].
Web ID
– HY-118922
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C22H23N3O3S2
References
– [1]Percy H. Carter, et al. Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11879-84.
CAS Number
– 389142-48-7
Molecular Weight
– 441.57
Compound Purity
– 99.04
SMILES
– O=C(C1=CC2=C(C=C(S2)C3=CC=CC(OC)=C3)N1C4=S)N4CCCN5CCOCC5
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– TNF Receptor
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
