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Ivosidenib
SKU
HY-18767-10 mg
Category Reference compound
Tags Cancer; Metabolic Disease, Isocitrate Dehydrogenase (IDH), Metabolic Enzyme/Protease
$80 – $624
Products Details
Product Description
– Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity[1].
Web ID
– HY-18767
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H22ClF3N6O3
References
– [1]Popovici-Muller J, et al. Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1Mutant Cancers. ACS Med Chem Lett. 2018 Jan 19;9(4):300-305.
CAS Number
– 1448347-49-6
Molecular Weight
– 582.96
Compound Purity
– 99.78
SMILES
– ClC1=C([C@H](N(C2=CC(F)=CN=C2)C([C@H]3N(C4=NC=CC(C#N)=C4)C(CC3)=O)=O)C(NC5CC(F)(F)C5)=O)C=CC=C1
Clinical Information
– Launched
Research Area
– Cancer; Metabolic Disease
Solubility
– DMSO : ≥ 39 mg/mL
Target
– Isocitrate Dehydrogenase (IDH)
Isoform
– IDH1
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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