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Products Details
Product Description
– ITK inhibitor 5 (compound 27) is a potent and selective ITK inhibitor with IC50s of 5.6, 25 nM for ITK, BTK, respectively[1].
Web ID
– HY-146671
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H18F2N4O2
References
– [1]Wang X, et al. Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK). Eur J Med Chem. 2020 Feb 1;187:111918.
CAS Number
– 2404603-41-2
Molecular Weight
– 396.39
SMILES
– C=CC(NCCOC1=C2C=C(NC2=CC=C1)C3=NNC4=C3C=CC(C(F)F)=C4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Itk
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
