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Products Details
Product Description
– ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1].
Web ID
– HY-13232
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H34N6O2S
References
– [1]Riether D, et al. 5-Aminomethylbenzimidazoles as potent ITK antagonists. Bioorg Med Chem Lett. 2009;19(6):1588-1591.
CAS Number
– 1149753-56-9
Molecular Weight
– 494.65
SMILES
– CC(C)(O)CN1C2=CC=C(CN[C@@H](C)C(C)(C)C)C=C2N=C1NC(C3=CC=C(C4=CNN=C4)S3)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Itk
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
