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ITH12575
$160 – $790
Products Details
Product Description
– ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2].
Web ID
– HY-117073
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H18ClNOS
References
– [1]Francisco J MartÃnez-Sanz, et al. Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36.|[2]Ana J Moreno-Ortega, et al. Benzothiazepine CGP37157 and its 2′-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology. 2015 Aug;95:503-10.
CAS Number
– 1802013-08-6
Molecular Weight
– 331.86
Compound Purity
– 99.14
SMILES
– O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3C(C)C)SC1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Calcium Channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
