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Product Description
– Isradipine-d6 is the deuterium labeled Isradipine[1]. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson’s disease[2][3][4].
Web ID
– HY-B0233S1
Shipping
– Room temperature
Molecular Formula
– C19H15D6N3O5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ilijic E, et al. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson’s disease. Neurobiol Dis. 2011;43(2):364-371.|[3]Campbell CA, et al. Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats. Exp Neurol. 1997;148(1):45-50.|[4]Hof RP, et al. Selective effects of PN 200-110 (isradipine) on the peripheral circulation and the heart. Am J Cardiol. 1987;59(3):30B-36B.
CAS Number
– 1261398-97-3
Molecular Weight
– 377.42
SMILES
– [2H]C([2H])([2H])C(C([2H])([2H])[2H])OC(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC3=NON=C23)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Autophagy;Calcium Channel
Pathway
– Autophagy;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Isotope-Labeled Compounds
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