Products Details

Product Description

– Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma[1][2][3][4][5][6].

Web ID

– HY-108353A

Shipping

– Room temperature

Applications

– Metabolism-sugar/lipid metabolism

Molecular Formula

– C11H17NO3.1/2H2O4S

References

– [1]M E Conolly, et al. Metabolism of isoprenaline in dog and man. Br J Pharmacol|[2]Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-K<sub>m</sub> cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7.|[3]Vannucci SJ, et al. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J. 1992 Nov 15;288 (Pt 1):325-30.|[4]Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol. 1996 Oct;119(3):471-8.|[5]Muller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993 Mar;72(3):696-700.|[6]Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000 Jan;85(1):27-35.

CAS Number

– 299-95-6

Molecular Weight

– 260.30

SMILES

– OC1=CC=C(C(O)CNC(C)C)C=C1O.O=S(O)(O)=O.[0.5]

Clinical Information

– Launched

Research Area

– Endocrinology; Cardiovascular Disease

Solubility

– 10 mM in DMSO

Target

– Adrenergic Receptor;Endogenous Metabolite

Isoform

– β adrenergic receptor

Pathway

– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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