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Products Details
Product Description
– Irbesartan-d6-1 is the deuterium labeled Irbesartan[1]. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[2].
Web ID
– HY-B0202S2
Shipping
– Room temperature
Molecular Formula
– C25H22D6N6O
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Schupp M, et al. Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation. 2004 May 4;109(17):2054-7. Epub 2004 Apr 26.|[3]Ruiz E, et al. Importance of intracellular angiotensin II in vascular smooth muscle cell apoptosis: inhibition by the angiotensin AT1 receptor antagonist irbesartan. Eur J Pharmacol. 2007 Jul 19567(3):231-9. Epub 2007 Apr 6.|[4]Yong Zhong, et al. Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension. Int Immunopharmacol
CAS Number
– 2375621-21-7
Molecular Weight
– 434.57
SMILES
– O=C1C2(CCCC2)N=C(N1C([2H])([2H])C3=C([2H])C([2H])=C(C4=C(C5=NN=NN5)C=CC=C4)C([2H])=C3[2H])CCCC
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Angiotensin Receptor;Apoptosis
Pathway
– Apoptosis;GPCR/G Protein
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
