Download Files:
Products Details
Product Description
– IRAK4-IN-28 (compound 42) is an orally active IRAK4 inhibitor (IC50=8.9 nM). IRAK4-IN-28 has binding affinity for IRAK4 with a Kd of 0.58 nM. IRAK4-IN-28 can be used in the research of inflammation and autoimmune diseases[1].
Web ID
– HY-155132
Shipping
– Room temperature
Molecular Formula
– C27H31N9O3
References
– [1]Yongjin Hao, et al. Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS-induced SIRS model. Bioorg Chem. 2023 , 137:106584.
CAS Number
– 2952532-92-0
Molecular Weight
– 529.59
SMILES
– CN1N=CC(C2=CC=CC(NC(C3=CC(O4)=C(N=C3N5CCN(C6CC6)CC5)N=C4N7CCOCC7)=O)=N2)=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– IRAK
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
