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Products Details
Product Description
– IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg[1].
Web ID
– HY-146111
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H27N9O
References
– [1]Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115815.
CAS Number
– 2667681-57-2
Molecular Weight
– 457.53
SMILES
– CN1CCC(N2N=CC(NC3=NC(OC4(C)CC4)=C5C(C=CC(C6=CN=CN=C6)=N5)=N3)=C2)CC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– IRAK
Isoform
– IRAK4
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
