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IRAK-1-4 Inhibitor I
$107 – $1,092
Products Details
Product Description
– IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.2 μM and 0.3 μM, respectively.
Web ID
– HY-13329
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H21N5O4
References
– [1]Powers JP, et al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-2845.|[2]Bhattacharyya S, et al. Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G429-37.
CAS Number
– 509093-47-4
Molecular Weight
– 395.41
Compound Purity
– 99.88
SMILES
– O=C(C1=CC=CC([N+]([O-])=O)=C1)NC2=NC3=CC=CC=C3N2CCN4CCOCC4
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMF : 25 mg/mL (ultrasonic;warming;heat to 60°C)|DMSO : 5 mg/mL (ultrasonic;adjust pH to 3 with HCl)
Target
– IRAK
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
