Download Files:
Iperoxo
$135 – $1,200
Products Details
Product Description
– Iperoxo is a potent superagonist of muscarinic acetylcholine receptor (mAChR). [3H]Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors[1][2]. Iperoxo is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-122743
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C10H17IN2O2
References
– [1]Schrage R, et, al. Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor. Br J Pharmacol. 2013 May;169(2):357-70.|[2]Schrage R, et, al. New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo. Biochem Pharmacol. 2014 Aug 1;90(3):307-19.
CAS Number
– 247079-84-1
Molecular Weight
– 324.16
Compound Purity
– 99.31
SMILES
– C[N+](C)(C)CC#CCOC1=NOCC1.[I-]
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– mAChR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
