IPA-3

$50$458

Products Details

Product Description

– IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, and shows no inhibition to group II PAKs (PAKs 4-6).

Web ID

– HY-15663

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C20H14O2S2

References

– [1]Deacon SW, et al. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol. 2008 Apr;15(4):322-31|[2]Flaiz C, et al. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurol. 2009 Jul;218(1):137-44.|[3]Viaud J, et al. An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther. 2009 Sep;8(9):2559-65.

CAS Number

– 42521-82-4

Molecular Weight

– 350.45

Compound Purity

– 99.43

SMILES

– OC1=CC=C2C=CC=CC2=C1SSC3=C4C=CC=CC4=CC=C3O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– PAK

Isoform

– PAK1

Pathway

– Cell Cycle/DNA Damage;Cytoskeleton

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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