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Products Details
Product Description
– iNOS/PGE2-IN-1 (compound 4a), an iNOS/PGE2 inhibitor, is a potent anti-inflammatory agent. iNOS/PGE2-IN-1 can inhibit LPS-induced NO production. iNOS/PGE2-IN-1 possesses low ulcerogenic liabilities[1].
Web ID
– HY-146167
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H22ClN3O4
References
– [1]Mohamed MFA, et, al. Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors. Bioorg Chem. 2020 Dec;105:104439.
Molecular Weight
– 475.92
SMILES
– N/C(C1=CC=CC=C1)=NOC(CC2=C(N(C3=C2C=C(OC)C=C3)C(C4=CC=C(Cl)C=C4)=O)C)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NO Synthase
Isoform
– iNOS
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
