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Inolitazone (dihydrochloride)
$300 – $2,680
Products Details
Product Description
– Inolitazone dihydrochloride (Efatutazone dihydrochloride) is a novel high-affinity PPARγ agonist that is dependent upon PPARγ for its biological activity with IC50 of 0.8 nM for growth inhibition.
Web ID
– HY-14792B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H28Cl2N4O4S
Citations
– Cancer Med. 2018 May;7(5):1955-1966. |Int J Oncol. 2018 Jun;52(6):1991-2000. |Exp Cell Res. 2017 Dec 15;361(2):246-256. |Front Microbiol. 2019 Jan 8;9:3257.
References
– [1]Marlow LA, et al. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb 15;69(4):1536-44.|[2]Copland JA, et al. Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene. 2006 Apr 13;25(16):2304-17.
CAS Number
– 223132-38-5
Molecular Weight
– 575.51
Compound Purity
– 98.86
SMILES
– O=C(N1)SC(CC2=CC=C(OCC3=NC4=CC=C(OC5=CC(C)=C(N)C(C)=C5)C=C4N3C)C=C2)C1=O.Cl.Cl
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 25 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;warming;heat to 10°C)
Target
– PPAR
Isoform
– PPARγ
Pathway
– Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
