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Indomethacin (sodium)
SKU
HY-15034-Get quote
Category Reference compound
Tags Anti-infection;Immunology/Inflammation, Antibiotic;Bacterial;COX;Influenza Virus, Cancer; Inflammation/Immunology
Products Details
Product Description
– Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research.[1][2][3].
Web ID
– HY-15034
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C19H15ClNNaO4
References
– [1]Riendeau D, et, al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.|[2]Amici C, et, al. Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR. Cell Microbiol. 2015 Sep;17(9):1391-404.|[3]Eli Y, et, al. Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. Biochem Pharmacol. 2001 Mar 1;61(5):565-71.
CAS Number
– 7681-54-1
Molecular Weight
– 379.77
SMILES
– O=C(O[Na])CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
Clinical Information
– Launched
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial;COX;Influenza Virus
Isoform
– COX-1;COX-2
Pathway
– Anti-infection;Immunology/Inflammation
Product type
– Reference compound
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