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Products Details
Product Description
– Indirubin-3′-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].
Web ID
– HY-111931
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H11N3O5S
References
– [1]Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.
CAS Number
– 331467-05-1
Molecular Weight
– 357.34
SMILES
– O=S(C1=CC2=C(NC(/C2=C3NC4=C(C=CC=C4)C/3=NO)=O)C=C1)(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK;GSK-3
Isoform
– CDK1;CDK5;GSK-3β
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
