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Indazole-Cl
$315
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Products Details
Product Description
– Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs)[1].
Web ID
– HY-137004
Shipping
– Room temperature
Molecular Formula
– C13H9ClN2O2
References
– [1]Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63(1):27-38.
CAS Number
– 848142-62-1
Molecular Weight
– 260.68
SMILES
– OC1=CC2=C(Cl)N(C3=CC=C(O)C=C3)N=C2C=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– COX;Estrogen Receptor/ERR
Isoform
– COX-2
Pathway
– Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
