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Products Details
Product Description
– IMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research[1][2].
Web ID
– HY-147660
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H28N2O3
References
– [1]Xiao Q, et al. Design and synthesis of analogues of the sphingosine-1-phosphate receptor 1 agonist IMMH001 with improved phosphorylation rate in human blood. Bioorg Med Chem. 2020 Nov 1;28(21):115722.|[2]Jin J, et al. Sphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced Arthritis. Front Pharmacol. 2019 Sep 19;10:1085.
CAS Number
– 1418093-75-0
Molecular Weight
– 380.48
SMILES
– CCCC1=NC(C2=CC=C(C=C2)C3=CC=C(C=C3)CCC(CO)(CO)N)=CO1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– LPL Receptor
Isoform
– S1PR1
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
