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Products Details
Product Description
– IMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research[1][2].
Web ID
– HY-147660
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H28N2O3
References
– [1]Xiao Q, et al. Design and synthesis of analogues of the sphingosine-1-phosphate receptor 1 agonist IMMH001 with improved phosphorylation rate in human blood. Bioorg Med Chem. 2020 Nov 1;28(21):115722.|[2]Jin J, et al. Sphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced Arthritis. Front Pharmacol. 2019 Sep 19;10:1085.
CAS Number
– 1418093-75-0
Molecular Weight
– 380.48
SMILES
– CCCC1=NC(C2=CC=C(C=C2)C3=CC=C(C=C3)CCC(CO)(CO)N)=CO1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– LPL Receptor
Isoform
– S1PR1
Pathway
– GPCR/G Protein
Product type
– Reference compound
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