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IMB-808
$90 – $825
Products Details
Product Description
– IMB-808 is a potent LXRα/β dual agonist with EC50 values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research[1].
Web ID
– HY-123148
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Molecular Formula
– C18H15F3N2O4
References
– [1]Duo Lu, et al. Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics. Mol Pharmacol. 2017 Apr;91(4):264-276.
CAS Number
– 870768-70-0
Molecular Weight
– 380.32
Compound Purity
– 99.85
SMILES
– O=C(N(CC(NC1=CC=C(C(F)=C1F)F)=O)C)C2=CC=C3OCCOC3=C2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– LXR
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
