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Product Description
– Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder[1][2][3].
Web ID
– HY-B1134A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C14H16Cl2N2O5S
References
– [1]Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):338-45.|[2]Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43(7):443-450.|[3]Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33(6):650-658.
CAS Number
– 58594-72-2
Molecular Weight
– 395.26
SMILES
– C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2.O=S(O)(O)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Fungal
Pathway
– Anti-infection
Product type
– Reference compound
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