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IHMT-PI3Kδ-372
$230 – $1,880
Products Details
Product Description
– IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research[1].
Web ID
– HY-131910
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H23F2N7O2
References
– [1]Feng Li, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1 H-pyrazolo[3,4- d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3 H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993.
CAS Number
– 2429889-62-1
Molecular Weight
– 503.50
Compound Purity
– 99.75
SMILES
– CC[C@H](C(N1C2CC2)=NC3=CC=CC(F)=C3C1=O)N4C5=NC=NC(N)=C5C(C6=CC(F)=C(C=C6)OC)=N4
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 41.67 mg/mL (ultrasonic)
Target
– Cytochrome P450;PI3K
Isoform
– CYP2;CYP3;PI3Kδ
Pathway
– Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
