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IFN alpha-IFNAR-IN-1 (hydrochloride)
$119 – $739
Products Details
Product Description
– IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM)[1].
Web ID
– HY-12836A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H18ClNS
Citations
– Adv Healthc Mater. 2023 Jan 30;e2202830.|Arthritis Res Ther. 2022 Jul 19;24(1):170.|Cell Death Dis. 2020 Dec 11;11(12):1050.|Cell Mol Life Sci. 2022 Jan 20;79(2):83.|Cell Rep. 2023 Feb 28;42(3):112145.|Clin Exp Immunol. 2020 Dec 23.|Exp Eye Res. 2021 Jan;202:108375.|Front Immunol. 2019 Oct 11;10:2391.|J Med Virol. 2023 Nov 7.|Mol Oncol. 2023 Sep 25.|Nature. 2022 Sep;609(7928):785-792.|Pharmacol Res. 2022 Dec 16;187:106615.|PLoS Pathog. 2022 Feb 14;18(2):e1010301.|Viruses. 2022, 14(8), 1806.|Arthritis Rheumatol. 2020 Jun;72(6):1003-1012.|Cell Rep. 2022 Nov 29;41(9):111738.|Free Radic Biol Med. 10 October 2022.|Front Immunol. 2019 May 3;10:980.|Sci Rep. 2016 Jul 14;6:29665.
References
– [1]Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61.
CAS Number
– 2070014-98-9
Molecular Weight
– 315.86
Compound Purity
– 99.87
SMILES
– CNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 16.67 mg/mL (ultrasonic)
Target
– IFNAR
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
