Download Files:
IEM-1754
$93 – $450
Products Details
Product Description
– IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].
Web ID
– HY-100547
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C16H32Br2N2
References
– [1]D B Tikhonov, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74.|[2]Tikhonov DB, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74.|[3]Lukomskaia NIa, et al. [Comparison of the anticonvulsant activity of organic mono- and di-cations and their potential to inhibit NMDA and AMPA glutamate receptors]. Ross Fiziol Zh Im I M Sechenova. 2002 Sep;88(9):1161-71. Russian.
CAS Number
– 162831-31-4
Molecular Weight
– 412.25
Compound Purity
– 98.03
SMILES
– NCCCCCNCC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.Br.Br
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– iGluR
Isoform
– AMPA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
