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Products Details
Product Description
– IDO1/TDO-IN-3 is a potent inhibitor of IDO1/TDO. IDO1/TDO-IN-3 exhibits significant activities against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM). IDO1/TDO-IN-3 shows considerable in vivo anti-tumor activity and no obvious toxicity is observed[1].
Web ID
– HY-146674
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H6ClF2N3O2
References
– [1]Pan S, et al. Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO). Eur J Med Chem. 2020 Dec 1;207:112703.
CAS Number
– 2347579-03-5
Molecular Weight
– 345.69
SMILES
– O=C1C2=CC(F)=CC=C2C(C3=C1N=NN3C4=CC=C(C(Cl)=C4)F)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Indoleamine 2,3-Dioxygenase (IDO)
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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