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Products Details
Product Description
– IDO1-IN-22 (Compound 3) is a IDO1 inhibitor (biochemical hIDO1 IC50: 67.4 nM, HeLa hIDO1 IC50: 17.6 nM). IDO1-IN-22 has excellent antitumor efficacy in LLC xenograft model, as well as desirable pharmacokinetic (PK) profile[1].
Web ID
– HY-149982
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C12H12BrFN6O3
References
– [1]Ye K, et al. Design, synthesis, biological evaluation of urea substituted 1,2,5-oxadiazole-3-carboximidamides as novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors. Eur J Med Chem. 2023 Mar 15;250:115217.
CAS Number
– 2126853-16-3
Molecular Weight
– 387.16
SMILES
– CCNC(NC1=NON=C1/C(NC2=CC=C(C(Br)=C2)F)=N/O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Indoleamine 2,3-Dioxygenase (IDO)
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
