Download Files:
Products Details
Product Description
– IDO1-IN-14 (compound 4a) is a potent IDO1 inhibitor with an IC50 of 396.9 nM. IDO1-IN-14 has cellular IDO1 inhibition (HeLa EC50=3393 nM)[1].
Web ID
– HY-144274
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H12Cl2FN3O2
References
– [1]Yeh TK, et al. Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design. Eur J Med Chem. 2022;229:114043.
Molecular Weight
– 392.21
SMILES
– O/N=C(C1=CN=C(C=C1)OC2=CC(Cl)=CC=C2)/NC3=CC=C(C(Cl)=C3)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Indoleamine 2,3-Dioxygenase (IDO)
Isoform
– IDO1
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
