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Idazoxan (hydrochloride)
$26 – $165
Products Details
Product Description
– Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2].
Web ID
– HY-14561A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C11H13ClN2O2
References
– [1]Roberto W Invernizzi, et al. The α2-Adrenoceptor Antagonist Idazoxan Reverses Catalepsy Induced by Haloperidol in Rats Independent of Striatal Dopamine Release: Role of Serotonergic Mechanisms. Neuropsychopharmacology volume 28, pages872-879 (2003).|[2]Bousquet P, et al. Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-like drugs. Ann N Y Acad Sci. 1999 Jun 21;881:272-8.
CAS Number
– 79944-56-2
Molecular Weight
– 240.69
Compound Purity
– 98.21
SMILES
– [H]Cl.C1(C2OC3=CC=CC=C3OC2)=NCCN1
Clinical Information
– Phase 3
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : 125 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– Adrenergic Receptor;Imidazoline Receptor
Isoform
– α adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
