iCRT 14

SKU HY-16665-10 mg Category Tags , ,

$84$624

Products Details

Product Description

– iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase.

Web ID

– HY-16665

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C21H17N3O2S

References

– [1]Gonsalves FC, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63.|[2]Bilir B, et al. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11:280.

CAS Number

– 677331-12-3

Molecular Weight

– 375.44

Compound Purity

– 99.29

SMILES

– O=C(S/1)N(C2=CC=CC=C2)C(C1=CC3=C(C)N(C(C)=C3)C4=CN=CC=C4)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : ≥ 29 mg/mL

Target

– Wnt

Pathway

– Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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