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Products Details
Product Description
– ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC50=0.015 μM). ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras[1].
Web ID
– HY-149705
Shipping
– Room temperature
Molecular Formula
– C23H31NO
References
– [1]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem. 2011 Jul 28;54(14):5031-47.
CAS Number
– 1313603-21-2
Molecular Weight
– 337.50
SMILES
– CC(C1)(C)OC(C)(C)CC1(CCNC2=CC=CC=C2)C3=CC=CC=C3
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– ICMT
Pathway
– GPCR/G Protein
Product type
– Reference compound
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