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Products Details
Product Description
– ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively[1].
Web ID
– HY-149729
Shipping
– Room temperature
Molecular Formula
– C26H36FN3
References
– [1]Ramanujulu PM, et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem. 2013 May;63:378-86.
CAS Number
– 1443253-17-5
Molecular Weight
– 409.58
SMILES
– FC1=C(C=CN=C1)C2=CC=C(N(CCCCCCCC)C=C3CN(CC)CC)C3=C2
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– ICMT
Pathway
– GPCR/G Protein
Product type
– Reference compound
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