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Products Details
Product Description
– ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 μM (1×Km SAM) and 2.3 μM (10×Km SAM), respectively[1].
Web ID
– HY-157116
Shipping
– Room temperature
Molecular Formula
– C30H37NO5
References
– [1]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem. 2011 Jul 28;54(14):5031-47.
CAS Number
– 337486-54-1
Molecular Weight
– 491.62
SMILES
– COC1=C(C(C2CC(C)(C)OCC2)CCN(C(C3=CC=CO3)=O)CC4=CC=C(OC)C=C4)C=CC=C1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– ICMT
Pathway
– GPCR/G Protein
Product type
– Reference compound
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