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Products Details
Product Description
– ICMT-IN-1 is a potent inhibitor of ICMT with an IC50 of 1.3 nM. ICMT-IN-1 can delay senescence and stimulate late-passage HGPS cells and Zmpste24-deficient mouse fibroblasts proliferation[1].
Web ID
– HY-156500
Shipping
– Room temperature
Molecular Formula
– C24H33NO2
References
– [1]Chen X, et al. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells. Elife. 2021 Feb 2;10:e63284.|[2]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem. 2011 Jul 28;54(14):5031-47.
CAS Number
– 1313603-22-3
Molecular Weight
– 367.52
SMILES
– CC(C)(C1)OC(C)(C)CC1(C2=CC=CC=C2)CCNC3=CC(OC)=CC=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ICMT
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
