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Products Details
Product Description
– IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX (HY-12318) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor[1][2][3][4][5].
Web ID
– HY-12318G
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C10H14N4O2
References
– [1]Tio M, et al. Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. PLoS One. 2010 Feb 24;5(2):e9398.|[2]Kim SP, et al. Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation. Biochem Biophys Res Commun. 2010 Aug 13;399(1):55-9.|[3]Lange A, et al. Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. Lung Cancer. 2011 Nov;74(2):178-87.|[4]Elks ML, Manganiello VC. A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes. J Cell Physiol. 1985 Aug;124(2):191-8.|[5]Ning H, et al. Insulin growth factor signaling mediates neuron-like differentiation of adipose-tissue-derived stem cells. Differentiation. 2008 May;76(5):488-94.
CAS Number
– 28822-58-4
Molecular Weight
– 222.24
SMILES
– O=C(N1C)N(CC(C)C)C2=C(N=CN2)C1=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
