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IACS-15414
SKU
HY-132901-10 mg
Category Reference compound
Tags Cancer, Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK, Phosphatase;SHP2
$291 – $2,510
Products Details
Product Description
– IACS-15414 is a potent and orally bioavailable SHP2 inhibitor with an IC50 value of 122 nM.
Web ID
– HY-132901
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H24Cl2N4O2
References
– [1]Czako B, et al. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 Oct 28;64(20):15141-15169.
CAS Number
– 2411321-29-2
Molecular Weight
– 423.34
Compound Purity
– 99.39
SMILES
– ClC1=CC=CC(N2C(C)=NC(N3CCC4([C@H](N)[C@H](C)OC4)CC3)=CC2=O)=C1Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Phosphatase;SHP2
Pathway
– Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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