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I-CBP112

$65$1,650

Products Details

Product Description

– I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor, that inhibits the CBP/p300 bromodomains, enhances acetylation by p300.

Web ID

– HY-19541

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C27H36N2O5

References

– [1]Zucconi BE, et al. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain LigandI-CBP112. Biochemistry. 2016 Jul 12;55(27):3727-34.|[2]Picaud S, et al. Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer Res. 2015 Dec 1;75(23):5106-19.

CAS Number

– 1640282-31-0

Molecular Weight

– 468.59

Compound Purity

– 98.46

SMILES

– COC1=C(OC)C=C(C2=CC(OC[C@H]3CCCN(C)C3)=C(OCCN(C(CC)=O)C4)C4=C2)C=C1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 1M HCl : 100 mg/mL (ultrasonic;adjust pH to 1 with HCl)|DMSO : ≥ 32 mg/mL

Target

– Epigenetic Reader Domain;Histone Acetyltransferase

Isoform

– CBP/p300

Pathway

– Epigenetics

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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