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Products Details
Product Description
– Hypericin-d10 is the deuterium labeled Hypericin. Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM.
Web ID
– HY-N0453S
Shipping
– Room temperature
Molecular Formula
– C30H6D10O8
References
– [1]Agostinis P et al. Hypericin in cancer treatment: more light on the way.
Int J Biochem Cell Biol. 2002 Mar;34(3):221-41.|[2]Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62.|[3]Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin.
Anticancer Res. 2001 Jul-Aug;21(4A):2649-55.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 514.50
SMILES
– O=C1C2=C(O)C([2H])=C(O)C3=C2C4=C(C5=C6C(O)=C([2H])C(C([2H])([2H])[2H])=C5C7=C4C1=C(O)C([2H])=C7C([2H])([2H])[2H])C8=C3C(O)=C([2H])C(O)=C8C6=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Influenza Virus;Isotope-Labeled Compounds
Pathway
– Anti-infection;Apoptosis;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
