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Hypericin
$66 – $462
Products Details
Product Description
– Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis[1][2][3].
Web ID
– HY-N0453
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C30H16O8
References
– [1]A Kubin, et al. Hypericin–the facts about a controversial agent. Curr Pharm Des. 2005;11(2):233-53.|[2]A Popovic, et al. Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model. J Photochem Photobiol B. 2015 Aug;149:249-56.|[3]Renata Sanovic, et al. Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma. Photodiagnosis Photodyn Ther. 2011 Dec;8(4):291-6.
CAS Number
– 548-04-9
Molecular Weight
– 504.44
Compound Purity
– 98.0
SMILES
– O=C1C2=C(O)C=C(O)C3=C2C4=C(C5=C6C(O)=CC(C)=C5C7=C4C1=C(O)C=C7C)C8=C3C(O)=CC(O)=C8C6=O
Clinical Information
– Phase 2
Research Area
– Cancer; Infection; Neurological Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Antibiotic;Apoptosis;Cytochrome P450;Dopamine β-hydroxylase;Influenza Virus;Monoamine Oxidase;PKC;Reverse Transcriptase;Telomerase
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease;Neuronal Signaling;TGF-beta/Smad
Product type
– Natural Products
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