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Product Description
– Hygrolidin is a 16-membered macrolide antibiotic produced by Streptomyces hygroscopicus D-1166. Hygrolidin has anti-fungus activity against Valsa ceratosperma. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Hygrolidin has antitumor activity[1][2][3].
Web ID
– HY-133537
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C38H58O11
References
– [1]Manabu Kawada, et al. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Biochem Biophys Res Commun. 2002 Oct 18;298(1):178-83.|[2]H Seto, et al. The isolation and structures of hygrolidin amide and defumarylhygrolidin. J Antibiot (Tokyo). 1984 May;37(5):610-3.|[3]F Annang, et al. High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease. J Biomol Screen. 2015 Jan;20(1):82-91.
CAS Number
– 83329-73-1
Molecular Weight
– 690.86
SMILES
– O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2C)OC2=O)C)(O)O[C@H](CC)[C@@H]1C)/C=C/C(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– ADC Cytotoxin;Antibiotic;Fungal
Isoform
– Macrolide
Pathway
– Antibody-drug Conjugate/ADC Related;Anti-infection
Product type
– Natural Products
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